Each Gelucire is characterized by two numbers, the first referring to the nominal melting point of the base and the second to the HLB value Gelucires come in a variety of grades with different melting points (from 33 ºC to 65 ºC) and HLB values (from 1 to 14) Mumbai Gelucire50/13 Gelucire44/14 and PEG6000 were obtained as giftGelucire 50/13 MinOrder 0 FOB Price USD $ 0000/ 1Our services：ASupply sampleBThe packing also can be according the customers` requirmentCAny inquiries will be replied within 24 hoursDwe provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificateThe dissolution rate of EVR from the optimized solid dispersion (SD) composed of the drug, gelucire 50/13 and microcrystalline cellulose in a weight ratio of 1510, was markedly rapid and higher
Woa2 Pharmaceutical Composition Comprising Solid Dispersion Of s Class Ii Drugs With Gelucires Google Patents
Gelucire 50/13 melting point
Gelucire 50/13 melting point-In another embodiment, the present invention discloses a solid pharmaceutical dosage form being tablets composed of BCS class II drug like TEL, in solid carrier/hydrophilic carrier in gelucire such as stearoyl polyoxyl32 glycerides NF (Gelucire® 50/13) having melting point 50° C and HLB value 13 with pH modifiers like sodium hydroxide, sodium bicarbonate, magnesium oxide, potassium hydroxide, meglumine, sodium carbonate, citric acid, tartaric acid, ascorbic acid, malic acid;The role of two carriers —Gelucire 50/13 and PEG — was evaluated to improve the characteristics of the dissolution of albendazole, an anthelmintic drug with very low solubility and dissolution rate (HME)— simplifies the dispersion of hydrophobic drugs into low melting point hydrophilic carriers as well as their processing into a
Enhanced Bioavailability Of Sirolimus Via Preparation Of Solid Dispersion Nanoparticles Using A Supercritical Antisolvent Process Abstract Europe Pmc
GLC 44/14 (Lauroyl polyoxyl32 glycerides, melting point 44 ℃, hydrophiliclipophilic balance 14) and GLC 50/13 (Stearoyl polyoxyl32 glycerides, melting point 50 ℃, hydrophiliclipophilic balance 13) was kindly provided by Gattefosse (Cedex, France)Other products, such as Gelucire® 48/16 and Gelucire® 50/13 are solids (higher melting points) and so are suitable also for preparation of granules and powders which can subsequently be filled into hard shell capsules or sachets Alternatively, the powders may be compressed into tabletsChemsrc provides Gelucire 14/44(CAS#) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc Articles of Gelucire 14/44 are included as well
For the Gelucire 50/13, the peak at 1075 cm −1 can be assigned to ν(C OH) (7 cm −1 in comparison with Rozenberg's results), the peak at 1095 cm −1 assigned to ν(C O) trans (−9 cm −1) and the peak at 1112 cm −1 assigned to ν(C O) gauche (−14 cm −1)Gelucire® 48/16 and Gelucire® 50/13 are solids (higher melting points) and so are suitable also for preparation of granules and powders which can subsequently be filled into hard shell capsules or sachets Alternatively, the powders may be compressed into tablets Generally, selfemulsifying formulations provide a rapid (immediateGelucire is derived from mixtures of mono, di and triglycerides with PEG esters of fatty acids These are available with range of properties depending on their HLB and melting point range of 33 to 65 °C They have a wide variety of applications in oral and topical formulation
IND with PEG4000 or Gelucire 50/13, at 11, 12 and 14 weight ratio of INDdrug, were prepared by blending them by trituration for 10 min followed by sieving (500 lm) 222 Preparation of solid dispersion Solid dispersions (SDs) at various weight ratios were prepared by melting method IND was added to the molten base comprising PEG4000 orGLC 44/14 (Lauroyl polyoxyl32 glycerides, melting point 44 ℃, hydrophiliclipophilic balance 14) and GLC 50/13 (Stearoyl polyoxyl32 glycerides, melting point 50 ℃, hydrophiliclipophilic balance 13) was kindly provided by Gattefosse (Cedex, France)Gelucire 50/13 is an excipient composed of fatty acid (C16 and C18) esters of glycerol, PEG esters and free PEG It melts at approximately 50°C and has hydrophiliclipophilic balance (HLB) value of 13 6 , 7
Raman Spectra Of Gelucire 50 13 A And B In The Spectral Region From Download Scientific Diagram
Dissolution Profiles Of Atorvastatin And Atorvastatin Gelucire Formulae Download Scientific Diagram
Gelucire® 50/13 Gelucire® 50/13 is a well characterized excipient, supported by numerous publications and worldwide precedence of use including FDA IID listing It has similar surfactive properties to Gelucire® 44/14 However with a higher melting point and longer fatty acid chains it can have a release retarding effect when used at highDrug,gelucire 50/13 and microcrystalline cellulose in aweight ratio of 1510, was markedly rapid and higher than that from the drug powder and the market product (Afinitor®, Novartis Pharmaceuticals) in all dissolution mediums tested from pH 30 to pH 68 Jammula S et al 13studied the effect of Gelucire 50/13 on dissoAdditionally, changes in polymorphism may occur and alter dissolution rates during storage (eg, Gelucire 50/13—HLB 13, melting point 50°C) Also other excipients such as sucrose esters, which would be stable up to 140°C ( 312 ) and are available with a promising high HLB of 16, showed polymorphic transformation during storage after melting ( 173 )
An Investigation Into The Mechanism Of Dissolution Rate Enhancement Of Poorly Water Soluble Drugs From Spray Chilled Gelucire 50 13 Microspheres Qi 10 Journal Of Pharmaceutical Sciences Wiley Online Library
Enhanced Bioavailability Of Sirolimus Via Preparation Of Solid Dispersion Nanoparticles Using A Supercritical Antisolvent Process Abstract Europe Pmc
Fig 6 demonstrates thermograms of IND, Gelucire 50/13, their PMs and SDs The endotherm of Gelu displayed broad peak appeared at 4656 °C corresponding to its melting point with heat of fusion −160 J/g (Khan and Craig, 03)Other products, such as Gelucire® 48/16 and Gelucire® 50/13 are solids (higher melting points) and so are suitable also for preparation of granules and powders which can subsequently be filled into hard shell capsules or sachets Alternatively, the powders may be compressed into tabletsFor example, GELUCIRE 50/13 designates a melting point of approximately 50° C and an HLB value of about 13 to this grade of GELUCIRE
Ir Spectra Of Pure Drug And Solid Dispersion Of Gelucire 44 14 O And Download Scientific Diagram
Differential Scanning Calorimetry For Different Atorvastatin Formulae Download Scientific Diagram
The wide varieties of gelucires are characterized by a wide range of melting points from about 33°C to about 64°C and most commonly from about 35°C to about 55°C, and by a variety of HLB values from about 1 to about 14, most commonly from about 7 to about 14Gelucires are defined by their melting point/HLB value As discussed previously, even though most Gelucires have Tm > 37°C, (the most frequently used for SLN/NLC formulation up to now is Gelucire 50/13), their Tm after processing to colloidal dimensions is expected to be decreased, leading to only partially crystallized lipid matrixWO PCT/IN15/ INW WO WO WO WO IN W IN W IN W WO WO WO Authority WO WIPO (PCT) Prior art keywords pharmaceutical composition solid tel carrier gelucire Prior art date Application number
Woa2 Pharmaceutical Composition Comprising Solid Dispersion Of s Class Ii Drugs With Gelucires Google Patents
Reported Literature On Gelucire 50 13 Download Scientific Diagram
42—46°C) and Gelucire® 50/13 (HLB 13, melting point 46—51°C) (Gattefossé, Saint Priest Cedex, France) were used All organic solvents were HPLC grade All other chemicals were analytical grade and doubledistilled water was used throughout the study The wide varieties of gelucires are characterized by a wide range of melting points from about 33°C to about 64°C and most commonly from about 35°C to about 55°C, and by a variety of HLB values from about 1 to about 14, most commonly from about 7 to about 14Legal notice Terms and condition © 21 Gattefossé People make our name
Epa1 Improved Fenofibrate Compositions Google Patents
Pdf Study On Mechanism For Amorphous Drug Stabilization Using Gelucire 50 13
